Are Carbohydrate Binding Proteins That Play A Vital Role...

Abstract: Selectins are carbohydrate-binding proteins that play a vital role in inflammatory responses. These proteins are involved in the homing of leukocytes and have been implicated in numerous diseases, including autoimmune diseases such as multiple sclerosis as well as various form of cancer. In addressing the role of selectins in autoimmune diseases, it has been found that they involved in the trafficking of immune cells to secondary lymphoid organs under normal conditions as well as to peripheral tissues during inflammation. Precise selectin–ligand interactions facilitate the recruitment of distinct immune cell subpopulations in specific target organs during autoimmune diseases. Additionally, selectins (and their ligands) are also vital for homeostasis and immune cell activation. Tissue-specific, selectin antagonists are fairly promising new therapeutic approaches for the treatment of autoimmune and inflammatory diseases, however, a more precise mechanism for selectin l eukocyte targeting must be uncovered first. Selectins also have been found to translate their roles in cellular adhesion to metastatic progression when the correct ligand is present. Though selectins have been identified as potential facilitators of metastasis, they have not been studied as drug targets for treating cancer progression and metastasis. However, targeting selectins as a cancer metastasis treatment could prove very successful as seen from initial positive clinical findings regarding heparinShow MoreRelatedThe Death Of Patients With Pneumococcal Pneumonia1185 Words   |  5 PagesThe leading cause of death in patients diagnosed with pneumococcal pneumonia is respiratory failure. Other causes include respiratory and systemic organ failure (3). The Streptococcus pneumoniae bacterium has a lethal role in causing respiratory failure in patients with pneumonia. This disease is infectious in humans of all ages, but children and the elderly are at higher risk (5). Pneumonia can be classified based on how you can contract it. The basic types of pneumonia include; community-acquiredRead MoreNGFR Case Study1237 Words   |  5 PagesDiscussion Novel serum markers are vital, in the case of malignancies such as NSCLC, not only for diagnosis but also for prognosis evaluation and follow-up of the patients after treatment(13). The EGFR is a strong biomarker candidate for multiple reasons. First, it is overexpressed in most of the NSCLC tumours. This overexpression, ultimately is causing increased proliferation or cell motility, and decreased apoptosis, leading to the progression of the tumour(27). Another appealing reason is theRead MoreInnate Immunity : An Early Phase Of Defence Mechanism Against Intruding Microorganisms5373 Words   |  22 Pagesactivation of complement, activation of coagulation cascades, activation of pro-inflammatory signalling pathways and induction of apoptosis (Janeway and Medzhitov, 2002). PRRs have many families such as membrane-associated Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), and the cytosolic NOD like receptors (NLRs), RIG-I-like receptors (RLRs), and AIM2-like receptors (ALRs). Immune responses (and the inflammatory response) in addition to pathogen recognition are activated by toll-like receptorsRead MoreAdipose Tissue : Overview Of Physiological Functions1625 Words   |  7 PagesBefore, body fat is simply known as a lipid droplet cell. Today, more studies and experiments are conducted in favor of examine the importance of adipose tissue’s function in the human body. Adipose tissue (body fat) has a significant physiological role to maintain body’s homeostasis. The following review will provide prominent knowledge of the adipose tissue’s development, structure, functions, and its relation to obesity. Adipose tissue is extremely essential for one’s health by performing as aRead MoreMolecular Basis Of Biology And Biotechnology4394 Words   |  18 PagesACRONYMS NSAIDs Non-steroidal anti-inflammatory drugs CCl4 Carbon tetrachloride SGOT Serum Glutamate Oxaloacetate Transaminase SGPT Serum Glutamate Puruvate Transaminase GGT Gamma Glutamyl Transferase MDA malondialdehyde HCC Hepatocellular carcinoma DCM Dichloromethane DMSO Dimethysulfoxide EDTA Ethylenediaminetetraacetic acid IP Intra-peritoneal ABSTRACT Liver plays a physiological role process in the human body bearing key roles like secretion of bile, vitamin storageRead MoreEssay6093 Words   |  25 Pages 12 11. Regeneration by liver progenitor cells (2nd line of defense) 13 12. Identifying the intrinsic liver stem cells 15 13. Physiological role of progenitor cells 16 14. Liver stem cell niche 17 15. Conclusion Read MoreMonitoring Assisted Reproductive Technology ( Icmart )9447 Words   |  38 Pagesendometrial wall of the uterus.3 In a study carried out in south western Nigeria, the common causes of infertility were: tubal factor (39.5%), uterine factor (30%), and ovarian factor (13%).5 Other causes included cervical factor (3%), pelvic inflammatory disease PID (5.5%), and endometriosis (2.5%).5 In-vitro Fertilization (IVF) treatment offers the highest pregnancy rate irrespective of the cause of infertility.6 The first successful IVF procedure was documented by Dr Edwards and Dr Steptoe inRead MoreSocm Study Guide Essay30404 Words   |  122 Pagesand physiology, and describe the various specialties within each discipline Anatomy – the study of internal and external structures and the physical relationship between body parts. Physiology – the study of how living organisms p0erform the vital functions. Microscopic Anatomy – study of structures that can not be seen by the naked eye. Cytology – analyzes the internal structure of individual cells. Histology – the study of tissues Gross Anatomy – considers features visible withRead MoreDual ACC1 / ACC2 Inhibition9209 Words   |  37 PagesNPY Y5-recombinant Baculovirus. The radioligand used was iodine-125 labeled PYY ligand. Herein the IC50 values of compounds 3a–n were less than 10 ÃŽ ¼M, with compounds having an IC50 of less than 500 nM or less than 100 nM.11 The results of this binding assay showed that these compounds may be used in treatment of disorders that are characterized by an excess of NPY, including cardiovascular diseases, renal system disorders, cerebral diseases, conditions of pain or nociception, abnormal foodRead MoreModule Quizzes Essay14245 Words   |  57 PagesReduced In the case of someone who wants to lose weight, they will be using the process of oxidation - losing electrons. They will want to oxidize their stored food in their fat cells. This is called _________ Catabolism A group of interconnected proteins called ____ hydrogen ions and electrons from the chemicals that make up our food. Enzymes In the case with the cell producing ATP; the more ATP that is generated the more the ATP generating machinery will shut down. This is an example of which

The Human Abstract Essay - 1196 Words

The Human Abstract The Human Abstract has not received much critical attention on its own. Of the critical interpretations that do exist, many approach the poem by examining its various manifestations in Blakes manuscripts, reading it against A Divine Image, a poem w hich was never finally published by Blake, or comparing it to its Innocence counterpart, The Divine Image. Most critics seem to agree that The Human Abstract represents a philosophical turning point in The Songs of Innocence and of Expe rience, and in Blakes work as a whole. In 1924, Joseph H. Wicksteed observes that this difficult poem, originally called The human Image, represents Blakes attempt to summarize his philosophy of revolt against the ob†¦show more content†¦He also approaches the poem through an examination of the four drafts located in Blakes manuscript, pointing out that critics have neglected to examine the way in which the poem A Divine Image is complexly operative in The Human Abstract. This connection is the foc us of the Gleckners essay, which he concludes with the contention that The Human Abstract represents Blakes final realization that the real disease is not a s ocial, economic, religious, [or] political force, but rather the cancerous tree of mystery...mans own thinking process. Later, both Geoffrey Keynes and David Erdman will point out that The Human Abstract replaced A Divine Image as the Experience response to The Divine Image. In Blakes Apocalypse: A Study in Poetic Argument, 1963, Harold Bloom reads The Human Abstract in conjunction with its Innocence partner, The Divine Image, noting that the word Abstract should not be misconst rued as literally meaning separated, because the contrast between the two poems is not between the integral and the split humanShow MoreRelatedThe Human Experience : An Abstract Concept Essay1371 Words   |  6 Pagesin which we attain knowledge is diversified by our ever-changing present circumstances. Human beings and their experiences are complex and diverse and should be imagined as such. Acquiring knowledge is an abstract concept that is happening constantly and rapidly. The human experience is full of constant acquisition of knowledge that comes to us through our own self-inquiry and the influence of others. Humans are conditioned to live in community and, therefore, base their understanding of themselvesRead MoreContradictions and Paradoxes in the Human Soul in â€Å"the Human Abstract†, by William Blake1110 Words   |  5 Pagesparadoxes in the human soul in â€Å"The Human Abstract†, by William Blake Before being good or bad, human beings are just humans who have to live with their own nature, which they sometimes cannot control. Man can do good or evil but he always makes it with a unique purpose, his personal satisfaction, because it is simply in his nature. Thus, human beings aware of good and evil are confronted with conflicting choices but they never act against their will. The poem, â€Å"The Human Abstract†, written by WilliamRead MoreAbstract Behavioral Development Is A Crucial Part Of Human1289 Words   |  6 PagesAbstract Behavioral development is a crucial part of human development. It influences how people interact with the atmosphere and others around them. Behavioral development is reliant on on many environmental factors which include one’s parents, siblings, peers, schooling and culture. According to Jacqueline J. Goodnow, these parental factors are often dependent on the culture in which the person was raised. The two parental factors that hav e a negative effect on a child’s behavioral and psychologicalRead MoreHuman Abstract : One Man s Attempt At Encapsulating The Human Condition1416 Words   |  6 Pages2015 The Human Abstract: One Man’s Attempt at Encapsulating the Human Condition William Blake’s â€Å"The Human Abstract† is a work that is trying to grasp the overall concept of humanity: how all people are connected through baser instincts. It is trying to create a map of human behavior and patterns, a broad, overall encompassment of what people act like: cruelty, mercy, fear, and love are not limited by class or status. Furthermore, Blake’s use of the word â€Å"abstract† is very clever, as human beingsRead MoreA Comparison of Blake’s Poems â€Å"the Divine Image† and â€Å"the Human Abstract†1090 Words   |  5 PagesErich Nolan CMLT-C205 3/19/12 A Comparison of Blake’s Poems â€Å"The Divine Image† and â€Å"The Human Abstract† William Blake (1757-1827, London) is considered the first of the great English Romantic poets; he was also a master engraver, a printer, and a painter. Blake was not widely known during his life and it wasn’t until some time after his death that his poetic works became widely read. Two of his best-known works â€Å"Songs of Innocence† (SoI) and â€Å"Songs of Experience† (SoE) contain the poemsRead MoreWilliam Blake s Poem, The Divine Image And The Human Abstract2156 Words   |  9 PagesOver time, man Christians who have a firm foundation in the Bible begin to develop and express their own theories. William Blake was one of these people. While he wrote many things, the poems â€Å"the Divine Image† and â€Å"the Human Abstract† from his books Songs of Innocence and of Experience hit on a deeper level inside of Christianity. When reading the works of others it is important to know what the actual gospel truth is and then what the poet’s tru th is. These lines are blurred in these two poemsRead MoreHuman Searches Of Databases Produced A Total Of 704 References And Abstract Records After Removal Of Duplicates.we Accessed 18967 Words   |  4 PagesOur searches of databases produced a total of 704 references and we screened 670 title and abstract records after removal of duplicates.We accessed 18 full-text papers for further full text screening to determine eligibility. We found 1 ongoing study (Badlani 2009) and four studies (Hajebrahimi 2011; Lee 2011; Xu 2007; Yamanishi 2004) fulfilled the inclusion criteria. A flow diagram of the process of selecting studies is presented in Figure 1. Included studies    A total of 322 females with VD inRead MoreDifferences Between Hylas And Philonous1191 Words   |  5 PagesAbstract ideas pertaining to epistemology in philosophy are almost as old as the concept of philosophy itself. Dating back to thinkers such as Aristotle, carrying on throughout the medieval period and into modern philosophy, abstracts have always been grappled with. George Berkeley’s epistemology about abstract ideas has historically been one that has drawn the attention of many other scholars and philosophical thinkers. His thoughts on ideas, specifically his expansion of Locke’s general abstractRead MoreBerkeley s Argument For The Dismissal Of Material Objects Essay1386 Words   |  6 Pagesthis argument, Berkeley details extensively how material objects, as humans have come to know them, do not exist. Berkeley uses a series of premises to aid in the elimination of skepticism surrounding the existence of the world humans have come to know and grow fond of. At f irst read, Berkeley’s conclusion that the abstract ideas of substance, matter, or any physical objects simply are not real is very hard to grasp when humans have based their justifications on what is real versus not real on theirRead MoreThe Ethics Of Care : An Argument Against Mill s Utilitarianism922 Words   |  4 Pagesapproach to without an emotional or relational value systems between human beings. In essence, an argument against Mill’s utilitarian Theory of Values will define Raskolnikov’s descent into criminality in the context of Held’s ethics of care philosophy of interpersonal relationships in the community. Virginia Held (2006) sought to bring a more emotional and non-abstracted evaluation of human relationships outside of the abstract reasoning of John Stuart Mill’s premise of a Theory of Values in utilitarian

Analysis of Caius Cassius Character free essay sample

The driving force behind the conspiracy is Cassius though there are others who are unhappy with the state of affairs under the prevailing system. Yet, they do not take an active part in the design to get rid of powerful Caesar. So, it is not incorrect to state that the chief protagonist of the assassination plot is no one but Caius Cassius. Let me have men about me that are fat; Sleek-headed men, and such as sleep onights: Yond Cassius has a lean and hungry look; He thinks too much: such men are dangerous. Act1. ii. In the Act 1 Scene ii of the play, we come across the above quotation where Caesar expresses, to Mark Antony, his assessment of Cassius’ personality although the latter plays down Caesar’s fear of Cassius stating that he is not a dangerous individual but a noble Roman. Caesar’s estimation of Cassius encapsulates in a nutshell the true face of a schemer who is out to deter, through jealousy or to gain personal advantages, the advancement of others. We do not know the truth behind this assertion. But Caesar believes firmly that Cassius is a person with evil intentions. Let us find out, based on the facts in the play, whether what Caesar believes is true. The initial appearance of Cassius, in the play, is in the Act 1. ii where he meets Brutus and joins him in conversation. Being a subtle thinker who visualizes everything from all standpoints, it is reasonable to conclude that he had not failed to pre-plan minutely the plot prior to his implanting the embryo, against Caesar, in Brutus’ mind. Cassius is crafty enough not to touch upon the topic directly. First he tries to find out Brutus’ personal opinion about Caesar’s authoritarian rule. So, he drifts the conversation towards that direction when Brutus drops the casual hint: â€Å"Nor construe any further my neglect Than that poor Brutus, with himself at war,† Act 1. ii. From this point onward, he manipulates on Brutus’ egotism by praising the noble role his ancestors had played in the past in the affairs of the country, and also Brutus for the high respect that the Romans have towards him. By means of this ingenious mechanism he tries to create in Brutus the normal human feeling â€Å"If people hold me in such esteem, I am better than Caesar. See the next question Cassius poses to Brutus: â€Å"Tell me, good Brutus, can you see your face? † Act 1. ii. How skilfully he plays his card to win Brutus over to his side! He handles the whole subject as an expert at negotiation. Cassius’ endeavour does not stop here. He pursues it still more vigo rously. Now it takes a different turn. He presents to Brutus a Caesar who is not as courageous or valiant as people think him to be. To buttress his claim, he relates two incidents where Caesar showed his cowardice. One of which is the incident where Cassius and Caesar jumped into the raging Tiber to swim to the other side. Before being able to reach the bank, Caesar got into difficulties and screamed for help. It was Cassius who saved him from drowning. What is Cassius driving at? Here he compares Caesar with Brutus and implies that, when there are greater men like Brutus, in the Republic of Rome, why should they remain passive under the yoke of a tyrant? This argument succeeds partially to win over Brutus’ co-operation for Cassius’ plan. It is a great achievement for him, for it is not a simple task to convince an idealist of the calibre of Brutus to commit an action that will spill out blood. After preparing the preliminary ground and getting Brutus’ consent to think over the subject, Cassius does not remain idle. He pursues the issue relentlessly to ensure that Brutus will not change his mind. He writes some notes, under different hands, as if coming from several citizens and causes them to be thrown into his room at night for him to read. The general tenor of the writing is that Rome holds Brutus in high esteem and respect and he should not be silent when the country is in dire need of his leadership to overthrow the tyrant. The strategy succeeds in obtaining Brutus’ whole-hearted involvement in the conspiracy when he says, â€Å"‘Speak, strike, redress! ’ Am I entreated To speak and strike? O Rome, I make thee promise, If the redress will follow, thou receivest Thy full petition at the hand of Brutus! † Act 2. ii. Though the method employed to convert Brutus is quite unprincipled, it shows, no doubt, the skill of a practical man to achieve his objective by hook or by crook. Hence, it can be counted as a plus point in his character. Brutus’ patriotism and self-love impede him from seeing the deep chasm to which he is pushed by artful manipulation. Unlike Brutus, Cassius is a far-sighted man. He is aware of the capability of Antony and his solid friendship with Caesar. An important item in his plan is to get rid of Mark Antony as well, along with Caesar since he concludes that he is a potential danger to their cause. But this is over-ruled by Brutus on the premise that it will foul their good intention. Brutus’ reaction to the suggestion is: â€Å"Let’s be sacrificers, but not butchers, Caius. † Act 2 Scene i. What takes place later fully justifies the stand taken by Cassius with regard to Antony. If Brutus agreed with Cassius, the conspiracy would have been a complete success. Brutus permits Antony to make a funeral oration at Caesar’s burial. Again Cassius objects to Antony being allowed to speak for he sees it dangerous, and this is his reaction: â€Å"You know not what you do. Do not consent That Antony speaks in his funeral. † Act 3 Scene i. Why did such a far-sighted man as Cassius, who felt that there was a potential threat from Antony in the event of him being allowed to live and permitted to deliver Caesar’s funeral oration, meekly succumb to Brutus’ objections and keep mute? As this is a relevant question which bears on Cassius’ true character, it is important that there is some acceptable explanation to the position adopted by him. It is a well-known fact that Cassius’ endeavour to get the co-operation of Brutus to assassinate Caesar is based on the hypothesis that it can succeed only if Brutus is their chief co-conspirator. Relying on this theory, he does not want to commit anything that is liable to displease Brutus. He thinks that, if Brutus is annoyed and comes to the conclusion that the assassination is done to achieve some personal ends and not for the common good of the country, Brutus will not hesitate to wash his hands off the plot. In order to prevent this possibility, Cassius remains silent and this is the serious weakness in his character. This finally becomes the fatal flaw in the bid to get rid of the dictatorship. If Cassius explained to Brutus in greater detail the danger of permitting Antony to deliver the funeral oration, the fatal end of the conspiracy could have been avoided. This is not in keeping with the manoeuvring skill of a man like Cassius. If he can convince Brutus to support the conspirators, it is not impossible for him to get Brutus to block Antony being given the opportunity of speaking at the funeral. Cassius is undoubtedly a superb schemer. He is able to win over to his side an idealist like Brutus to assassinate his good friend, Caesar. However, he fails in his endeavour to liquidate Mark Antony and block his delivering the funeral oration at Caesar’s burial. His failure to explain the inherent dangers posed by Antony convincingly to Brutus, who does not see the reality due to his extreme idealism, is an indelible black mark on his character as a skilful schemer. Though the conspirators succeed in assassinating Caesar, yet they get themselves liquidated as a result of Mark Antony’s dexterous manipulation of the popular anger against them. So, Cassius and Brutus should be held responsible for the unnecessary massacre that ensues and both of them kill themselves by their own hands before they are captured by the forces commanded by AntonÃ'Æ'.

Should Athletes Get Paid free essay sample

Should college Athletes Be Paid to play These days athletes are getting paid under federal labor laws and entitled to form unions and negotiate wages, hours and working conditions. Most college athletes these days are getting paid under the table according to Kenneth J. Cooper. This article explains why college athletes go to certain colleges. Donald Remy, the NCAA’s general counsel and vice president for legal affairs, says court precedents and tax laws have upheld the status of college athletes as students. Remy believes that student athletes are not employees under the law, and that they should not be treated as employees either by the law or by the schools they attend†. Tommy Amaker a former basketball star at Duke University now coaches at Harvard university men’s team said he could of got his education paid for at an incredible school but he didn’t want to. To me I think I would of did the same thing because I wouldn’t want free money that I di dn’t work for or didn’t win. We will write a custom essay sample on Should Athletes Get Paid or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page If he would of took it and got caught he would most likely get in trouble and duke university would have to get theirs wins and their banners token down. They would have to get their wins and banners taken down because once you violate the NCAA rule that’s what the NCAA does because no one likes someone that breaks rules. I would for sure think they would get in trouble because the same thing happen to Derrick Rose and John wall for taking money from the university. When his teammates found out they were upset because all their hard work before and after the season didn’t even matter anymore. In this article it also talks about college athletes going to college but not for a education for the college experience, and to make it pro. I really agree with this because most college athletes would want to go pro and make the big bucks but sometimes it doesn’t always work like that. For example my cousin didn’t want an education all he wanted to do was make the big bucks and that’s what he did. Many at major collegiate programs never get a degree the NCAA’s own statistics show. Former players who did graduate may be less inclined to think they were employee athletes as the McCormicks call them. Do you think people play D1 sports for the love of the game or for a job? To me most people play for the love of the game and some play because their getting paid and to me when you get paid to play that’s not right. Both Amaker and Hicks went to private schools and you woundlt think private schools would pay their players but they sure did. It doesn’t matter what school you go to most students are going to get some type of money.