Are Carbohydrate Binding Proteins That Play A Vital Role...

Abstract: Selectins are carbohydrate-binding proteins that play a vital role in inflammatory responses. These proteins are involved in the homing of leukocytes and have been implicated in numerous diseases, including autoimmune diseases such as multiple sclerosis as well as various form of cancer. In addressing the role of selectins in autoimmune diseases, it has been found that they involved in the trafficking of immune cells to secondary lymphoid organs under normal conditions as well as to peripheral tissues during inflammation. Precise selectin–ligand interactions facilitate the recruitment of distinct immune cell subpopulations in specific target organs during autoimmune diseases. Additionally, selectins (and their ligands) are also vital for homeostasis and immune cell activation. Tissue-specific, selectin antagonists are fairly promising new therapeutic approaches for the treatment of autoimmune and inflammatory diseases, however, a more precise mechanism for selectin l eukocyte targeting must be uncovered first. Selectins also have been found to translate their roles in cellular adhesion to metastatic progression when the correct ligand is present. Though selectins have been identified as potential facilitators of metastasis, they have not been studied as drug targets for treating cancer progression and metastasis. However, targeting selectins as a cancer metastasis treatment could prove very successful as seen from initial positive clinical findings regarding heparinShow MoreRelatedThe Death Of Patients With Pneumococcal Pneumonia1185 Words   |  5 PagesThe leading cause of death in patients diagnosed with pneumococcal pneumonia is respiratory failure. Other causes include respiratory and systemic organ failure (3). 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